Coiled bodies without coilin.
نویسندگان
چکیده
منابع مشابه
Coiled bodies without coilin.
Nuclei assembled in vitro in Xenopus egg extract contain coiled bodies that have components from three different RNA processing pathways: pre-mRNA splicing, pre-rRNA processing, and histone pre-mRNA 3'-end formation. In addition, they contain SPH-1, the Xenopus homologue of p80-coilin, a protein characteristic of coiled bodies. To determine whether coilin is an essential structural component of...
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A dystroglycan ligand in the brain ystroglycans are present on the surfaces of cells throughout the body, anchoring cells in the matrix that surrounds them. This function is conspicuously important for muscle cells. Defects in the protein dystrophin, which is D connected to dystroglycan, destabilize the connection of muscle cells to their matrix and cause muscular dystrophy. Dystroglycans are a...
متن کاملp80-coilin: a component of coiled bodies and interchromatin granule-associated zones.
We investigated at the electron microscope level the fate of the three intranuclear structures known to accumulate snRNPs, and which correspond to the punctuate immunofluorescent staining pattern (the coiled bodies, the clusters of interchromatin granules and the interchromatin granule-associated zones) after exposure to either a low salt medium which induces a loosening and partial spreading o...
متن کاملMutational analysis of p80 coilin indicates a functional interaction between coiled bodies and the nucleolus
Coiled bodies are conserved subnuclear domains found in both plant and animal cells. They contain a subset of splicing snRNPs and several nucleolar antigens, including Nopp140 and fibrillarin. In addition, autoimmune patient sera have identified a coiled body specific protein, called p80 coilin. In this study we show that p80 coilin is ubiquitously expressed in human tissues. The full-length hu...
متن کاملMicroinjection of Anti-coilin Antibodies Affects the Structure of Coiled Bodies
The coiled body is a distinct subnuclear domain enriched in small nuclear ribonucleoprotein particles (snRNPs) involved in processing of pre-mRNA. Although the function of the coiled body is still unknown, current models propose that it may have a role in snRNP biogenesis, transport, or recycling. Here we describe that anti-coilin antibodies promote a specific disappearance of the coiled body i...
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ژورنال
عنوان ژورنال: Molecular Biology of the Cell
سال: 1997
ISSN: 1059-1524,1939-4586
DOI: 10.1091/mbc.8.1.73